骨诱导素修复肿瘤性骨缺损

ABSTRACTOSTEOINDUCIN IN REPAIRING BONE DEFECTS FOLLOWING TUMOR RESECTION

骨诱导素是一种新型生物材料，其内含有骨形态发生蛋白（ＢＭＰ），它具有较强的诱导成骨作用已被实验研究证实。１９９２年以来，临床应用骨诱导素治疗肿瘤性骨缺损７例，取得了较好的效果。对该材料的性能、手术方法及适应证作了介绍，并与其它人工骨作了比较，认为该材料具有成骨作用快、组织相容性好、使用方便等优点，是一种理想的骨移植材料。

steoinducin is a kind of new biomaterial,which contains bone morphogenic protein(BMP).Its role of inducing osteosis has been confirmed by laboratory study. Since 1992, os-teoinducin was applied to treat tumorous defects of bone for 7 cases.After eradication of the le-sion of tumor,stick or granule-like osteoinducin was filied in the defects.In 8 weeks,the bonedefects had the sign of osteosis on roentgenogram. No rejection reaction and local inflammationwere found. The property, operation procedure and indication were introduced.Compared withother artificiai bones,the osteoinducin showed faster osteosis.better histocompatibility and moreconvenient usage. It was a good material for bone graft.