摘要
通过骨形态蛋白(BMP)与其前身物质骨基质明胶(BMG)复合,修复家兔桡骨缺损,同时以BMP与羟基磷灰石(HA)复合作实验对照。结果发现:BMP/BMG复合组第4周即在骨缺损区出现纤维性骨痂,第8周可见大量的骨小梁形成,第12周BMP完全被吸收,为新生的骨组织所代替,第16周出现髓腔再通现象。而BMP/HA复合组,虽然在第4、8周也有纤维性骨痂形成,但HA不被吸收;第12、16周与第8周相似,无髓腔再通现象。实验表明:BMP/BMG复合材料是修复骨缺损的一种较理想材料。
epair of bone defect by com pound of bone morphogenic
protein(BMP)and its prior bonematrix getatin(BMG) was compared with repair by BMP with
hydroxyapatite(HA).The re-sults showed that the BMP/BMG group was found fibrous callus in
the bone defect in 4th week. In 8th week a large quantity of osseos trabecula was found.In 12th
week the BMP was absorbedcompletely and was replaced by newly forn1ed bone.In 16th week
the recanalization appeared inthe bone cavity. While in the BMP/HA group,although the fibrous
callus was appeared in the4th and 8th weeks,the HA was not absorbed.In the 12th and 16th
weeks the change was simi-lar to that in the 8th week and no recanalization of bone marrow
cavity. It was suggested theBM P/BMG compound might be an ideal material to repair the bone
defect.
出处
《中国修复重建外科杂志》
CAS
CSCD
1995年第4期229-232,共4页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
骨缺损
修复术
骨形态蛋白
骨基质明胶
Bone morphogenic protein
Bone matrix gelation
Hydroxyapatite,Bone defect.