冠心病患者血清免疫球蛋白E水平的动态观察

STUDIES ON SERUM IgE LEVEL IN PATIENTS WITH CORONARY ARTERY DISEASE

采用酶联免疫吸附试验测定１３０例冠心病患者血清免疫球蛋白Ｅ（ＩｇＥ）含量。结果显示：急性心肌梗死（ＡＭＩ）组和不稳定心绞痛（ＵＳＡＰ）组显著高于稳定性心绞痛（ＳＡＰ）组和对照组（Ｐ＜０．００１）；ＡＭＩ组显著高于ＵＳＡＰ组和对照组（Ｐ＜０．０１）；而ＳＡＰ组与对照组无显著差异（Ｐ＞０．０５）。ＡＭＩ组发病后血清ＩｇＥ水平逐渐升高，至发病后第７天达高峰，以后逐渐下降，至２１天时降至初始水平。心肌梗死后无并发症组血清ＩｇＥ水平较有严重并发症组显著升高（Ｐ＜０．００１），但二者的动态波动规律一致。

Serum IgE levels were measured with enzyme linked immmunosorbent assay (ELISA) in 130 patients with coronary artery disease. The results showed that IgE levels were significantly higher in patients with acute myocardial infarction(AMI) and unstable angina pectoris(USAP) , compared to those with stable angina pectoris(SAP) (p<0. 001) and controls(p<0. 001).There was also significant difference between IgE levels in patients with AMI and USAP(p<0. 01). Although the IgE level was significantly lower in patients with severe complications than in those with no complications, their pattern of dynamic changes after AMI was similar.