摘要
长QT间期伴扭转型室性心动过速(TdP)是临床上常见的严重心律失常。TdP的发生机制已有研究,表明可能与触发机制有关。本文对3例不同病因的长QT间期综合征(LOTS)伴TdP的电生理和心内膜单相动作电位记录进行了研究。观察到如下特点:①心室刺激(程序或递增刺激)结合异丙肾上腺素静脉注射均不能诱发室性心律失常;②全部患者心电图上均能记录到巨大U波;③2例患者,在右心室内膜单相动作电位复极化[3]相期记录到一个驼峰形波,即为后去极化(EAD),该驼峰形波与体表心电图上巨大U波同步发生。本研究表明EAD在LQTS伴TdP的发生中可能起重要作用。
Torsade de points (TdP) with long QT interval is a common serious arrhythmia. The mechanism of TdP is not clear. The electrophysiology and endocardial monophasic action potential (MAP) recording in three patients with long QT interval syndrome (LQTS) and TdP of different etiology were studied. The following features were observed: (1) Ventricular arrhythmias could not be induced by ventricular endocardial stimuli (3 cases) and i. v. isoproterenol (2 cases); (2) Large u waves were recorded in three patients with LQTSTdP on the ECG; (3) In two cases, hump waves (early afterdepolarization, EAD) on the repolarization 3 phase of MAP corresponding to the u wave of surface ECG were recorded. This study showed that EAD may play a role in the genesis of LQTS-TdP.
出处
《中国循环杂志》
CSCD
1995年第6期329-331,共3页
Chinese Circulation Journal
关键词
QT间期综合征
心动过速
早期后去极
电生理
Pause-dependent long QT interval syndrome
Ventricular tachyarrythmia
Eqdocardial monophasic action potential recording
Early afterdepolarization