低温对发育未成熟心肌缺血保护的实验研究

EFFECT OF HYPOTHERMIA ON THE PROTECTION OF IMMATURE MOUSE MYOCARDIUM FROM ISCHEMIC DAMAGE

器官培养心脏在无低谢基质加乏氧条件下（以下简称缺血培养）３小时，４℃时心脏立即停跳，再有氧２４小时心脏搏动功能、超微结构恢复正常；３７℃时心肌发生不可复性损伤，搏动异常。４℃低温对未成熟心肌缺血具有朗好的保护作用。

Cultured fetal mmice hearts deprived of glucose and oxygen for 3 hours were used to study the effect of temperature on isehemic damage. At l((n=8), the hearts ceased beating immediately, after 24 hours in culture medium with oxygen and glucose, the ultrasturcture of heart cells returned to normal. At 37 C (n=8), the heart cells showed irreversible damage, and at 20 C(n=8).showed reversible damage. Thus, 4C protects well the immature myocardium from ischemia damage.