持续与间断静脉滴注多巴酚丁胺对充血性心力衰竭患者临床疗效对比分析

EFFECTS OF CONTINUOUS AND INTERMITENT INTRAVENOUS DOBUTAMINE IN CONGESTIVE HEART FAILURE

本文采用持续与间断静脉滴注多巴酚丁胺治疗充血性心力衰竭，发现间断静脉滴注多巴酚丁胺用药时间短，输入液体少、仍可明显改变血流动力及临床心功能状况，并可避免持续用药所产生的耐药性，且副作用小，在治疗充血性心力衰竭上更优于持续静脉滴注多巴酚丁胺。

Thirty nine patients with congestive heart failure were randomly assigned to receive continuous infusion of dobutamine(5 μg kg-1/min for 24 h/d,400 mg/d,n=19,group I) and intermittent infusion(5 μg kg-1/min for1.5 h/d,20 mg/d, n=20,group Ⅱ) for 7 days.The hemodynamic data showed that stroke volume and cardiac output were significantly increased in group Ⅱ tp<0.01 and p<0.05,respectively).There were obviously increased heart rate(p<0.05) and myocardial oxygen comsumption(p<0.05) and raised serum AT Ⅱ(p<0.01 )and more side effects in group Ⅰ.The drug was tolerated well by patients in group Ⅱ.It is concluded that.intermittent is better than continuous intravenous dobutamine for the treatment of patients with congestive heart failure.