摘要
连续１２例意外死亡的广西自治区南宁市年轻人（１５～３４岁）免疫组化染色证明，其主动脉及冠状动脉内膜的平滑肌细胞含有较多结蛋白。南宁是我国动脉粥样硬化最低发区之一，也是世界低发区。结蛋白阳性是平滑肌细胞成熟的标志。成熟平滑肌细胞为收缩型细胞，不易受生长因子作用而活跃增殖。因而认为这可能是动脉粥样硬化低发区的特征。与北京相比较，本地区动脉壁含较多具有抗增殖活性的硫酸乙酰肝素蛋白聚糖。平滑肌细胞产生这种聚糖构成细胞外层，像筑茧自缚一样抑制自身生长，因而平滑肌细胞比较成熟稳定，显示较多结蛋白。
In a consecutive series of 12 autopsied cases (15 to 34 yrs)of accidental death in Nanning,desmin -positive intimal smooth muscle cells (SMC) of the aortae and coronary arteries were found by immunohistochemistry.The prevalence rate of atherosclerosis (AS) in Nanning is the lowest in China and in the world as well. It is believed that desmin-peitivity is a marker of maturity of SMC ,which is of contractile phenotype and not actively responsive to the stimulation of growth factors. The present finding of desmin-positive intimal SMCs of arteries might be a characteristic feature of low prevalence of AS.
出处
《中国循环杂志》
CSCD
1995年第9期539-541,共3页
Chinese Circulation Journal
基金
"八五"医学科技攻关项目
