静脉注射卡托普利对先天性心脏病肺动脉高压患者的血液动力学及激素变化的研究

ACUTE HEMODYNAMIC AND HORMONAL CHANGES OF INTRAVENOUS CAPTOPRIL IN PATIENTS WITH CONGENITAL HEART DISEASES AND PULMONARY HYPERTENSION

以３０例先天性心脏病肺动脉高压患者为对象，观察静脉注射卡托普利后血液动力学及激素的变化。结果表明，静脉注射卡托普利能快速降低肺动脉压力，改善血液动力学，同时抑制肾素系统活性，降低血浆心钠素水平。卡托普利能鉴别肺动脉高压的类型，也可作为术前降压的药物。

The changes of hemodynamics and plasma hormones with intravenous(iv)captopril were studied in 30 patients with congenital heart diseases and pulmonary hypertension. The results indicated that intravenous captopril rapidly decreased pulmonary hypertension and improved the hemodynamics (p<0.05￣0.001), meanwhile inhibited plasma renin activity (p<0.001), decreased plasma Ang Ⅱ, Ald and ANF concentrations (p<0.005￣0.001). Furthermore, captopril (iv) can be used to differentiate the types of pulmonary hypertension and decrease hypertension before surgery.