苯妥英钠、卡马西平在血清、血清超滤液、唾液中浓度的监测和相关性探讨

Determination of the Concentrations of Phenytoin and Carbamazepine in Serum,Serum Ultrafiltrate$and Saliva and Study of the Correlations Between them

本文应用超滤法测定血清中游离苯妥英钠、卡马西平浓度。并采用荧光偏振免疫法对患者血清、血清超滤液进行２种抗癫痫药物的测定及唾液中苯妥英钠液度的测定，研究它们的相关性。实验结果表明：唾液、超滤液中苯妥英钠浓度分别为血清药物浓度的１０．６３％和９．５１％，超滤液中卡马西平浓度为血清药物浓度的２２．５８％，且均具有良好的相关性，通过回收率及重现性试验证明本方法可用于常规监测。

The concentrations of free phenytoin and carbamazepine in serum were determined by ultrafiltration, and the concentrations of both antiepileptics in serum and serum ultrafiltrate and that of phenytoin in saliva were detected with fluorescence polarization immunoassay.The correlations between them were analysed.The results showed that the concentrations of phenytoin in saliva and ultrafiltrate were 10.36% and 9.51% of those in serum respectively and the concentration of carbamazepine in ultrafiltrate was 22.58 % of that in serum. There were good correlations between them.