摘要
本文采用反相ＨＰＬＣ法测定压平乐健康人血清浓度，并对压平乐片的药动学进行了研究。色谱柱为ＳｐｈｅｒｉｓｏｒｂＣ１８，４．６×１５０ｍｍ，流动相为甲醇－０．０２Ｍ磷酸氢二铵（９：１）。检测波长为２２７ｎｍ，流速０．５ｍｌ／ｍｉｎ。用ＰＫＢＰ－Ｎ１程序拟合血浓－时间曲线，结果符合一室模型，其半衰期为ｔ１／２＝７．２１±０．８９ｈ。
The serum concentrations of Atenolol were determined bv RP～HPLC andthe pharmacokinetics of Atenolol was studied with column of spherisorb C18 and a mobile phase of methanol-diammonium hydrogen phosphate(9:1)The detection wave length was 227nm and flow rate 0.5ml/min The results showed that the pharmacokinetics of Atenolol could be described by a single compartment model.The half life time was 7.21±0.89h.
出处
《中国药房》
CAS
CSCD
1995年第6期28-29,共2页
China Pharmacy
