安心酮注射剂研制及其稳定性研究

Studies on Oxyfedrine Hydrochloride Injection and Its Stability

以正交设计筛选处方，研制了安心酮注射剂，考察了制剂的稳定性，有效期为２．８５年。采用酸性染料比色法测定注射剂中安心酮的含量，平均回收率为９８．７％（ＲＳＤ＝０．４４％）。本品对离体灌流豚鼠心脏的作用与原药相似。

Oxyfedrine Hydrochloride Injection was developed and its stability was studied.A quantitative analysis by acid dye colorimetry was used to measure the contents of oxyfedrine hydrochloride in the injection.The average recovery of oxyfedrine in oxyfedrine injection was 0.7%(RSD=0.44%).This injection was able to increase apparently the heart rate,coronary flow,and myocardial contractility when the hearts of Guinea pig were tested in vitro.The effect of Oxyfedrin HY-effect of Oxyfedrine Hydrochloride Injection to heart was similar to that of oxyfedrine hydrochloride.