关附庚素对麻醉大鼠血流动力学的影响

Hemodynamic Effects of Guanfu Base G in Anesthetized Rats

研究了关附庚素（２．５，５ｍｇ·ｋｇ－１，ｉｖ）对麻醉大鼠血流动力学的影响，并与心律平（５ｍｇ·ｋｇ－１，ｉｖ）的作用相比较。关附庚素（５ｍｇ·ｋｇ－１，ｉｖ）与心律平（５ｍｇ·ｋｇ－１，ｉｖ）均可显著延长Ｐ－Ｐ间期，Ｐ－Ｒ间期，ＱＲＳ波以及Ｑ－Ｔ间期，但关附庚素的作用更持久。关附庚素２．５ｍｇ·ｋｇ－１ｉｖ可显著降低ＨＲ，并一过性抑制ＳＡＰ，ＤＡＰ以及＋ｄｐ／ｄｔ（ｍａｘ），但不影响ＬＶＳＰ，＋ｄｐ／ｄｔｍａｘ（ｄｐ／ｄｔ）·以及ＬＶＥＤＰ。关附庚素５ｍｇ·ｋｇ－１ｉｖ和心律平５ｍｇ·ｋｇｉｖ可显著降低ＳＡＰ、ＤＡＰ同时伴有ＬＶＳＰ，±ｄｐ／ｄｔｍａｘ，（ｄｐ／ｄｔ）·以及ＨＲ的降低；但关附庚素对ＨＲ和（ｄｐ／ｄｔ）·的作用持续更久。而心律平对ＳＡＰ、ＤＡＰ以及ＬＶＳＰ的影响较关附庚素更显著和持久。上述结果提示，关附庚素对血流动力学的影响是剂量依赖性的，关附庚素较之心律平抑制心内冲动传导作用更持久，而对动脉血压影响较小。

The hemodynamic effects of Guanfu base G(GFG) were investigated and compared with those of propafenone in anesthetized rats.Both drugs significantly prolonged the P-P interval,P-R interval, QRS complex and Q-T interval,but the effects of GFG(5 mg·kg-1,iv)on P-P interval and P-R interval remained longer than those of propafenone(5 mg·kg-1,iv).The effect of GFG on Q-T interval was least and reversible most quickly among the four ECG parameters.GFG(2.5 mg·kg-1,iv) decreased HR markedly,SAP, DAP and +dp/dt(max) temporarily.The slight changes in LVSP.-dp/dt(max),(dp/dt) and LVEDP were not significant.GFG(s mg·kg-1, iv) and propafenone(5 mg·kg-1,iv) produced siginificant reduction in SAP and DAP accompanied with the depression in LVSP,±dp/dt(max),(dp/dt) and HR simultaneously, but the effects of GFG on HR and(dp/dt) remained longer.Propafenone resulted in much more pronounced and longer reduction than GFG in SAP,DAP and LVSP.Neither the drug caused profound increase in LVEDP.The reducing effects of GFG on hemodynamic parameters were dose-dependent.The present results show that GFG exerts negative inotropic and chronotropic effects on the heart,and GFG depresses intracardiac impulse conduction for longer time and affects the arterial prassure less than propafenone.