摘要
利用离体大鼠皮肤为渗透屏障,研究了祛寒理气涂膜剂中葛缕酮在促吸剂氮酮作用下的透皮效果。用气相色谱法测定葛缕酮。氮酮的促吸作用在一定浓度范围内随着浓度增加而增加,2%的氮酮促吸效果最佳,稳态流量为1701.0μg·cm-2。
The effect of penetration enhancers on the pormeability of carvone from Quhanliqi smeared film through excised rat skin in vitro was examined using the Franz diffusion cell and the normal saline as receptor medium.The results showed that the penetration rate of carvone from the smeared film containing enhancer Azone increased with the concentration of Azone increasing accordingly in the appropriate concentration range of Azone.The 2%(W/V) Azone had the best penetration effect on the carvone from smeared film through rat skin.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1995年第3期152-153,共2页
Journal of China Pharmaceutical University