黄芩甙对过氧化脂质生成的抑制作用

Inhibitory Effects of Baicalin on Lipid Peroxidation

研究了从黄芩中提取得到的黄芩甙的抗氧化作用。ＮＩＨ小鼠ｐｏ２５，５０ｍｇ／ｋｇ／ｄ黄芩甙，连续３ｄ，可以显著抑制ｉｐＦｅＣｌ２－ＡＤＰ－ＮＡＤＰＨ混合物诱导的过氧化脂质的生成，抑制率分别为７５％和８４％；体外试验，０．１，０．２和０．４ｍｍｏｌ／Ｌ的黄芩甙可以显著抑制由ＦｅＣｌ２－ＡＡ和ＡＤＰ－ＮＡＤＰＨ诱导的大鼠肝匀浆过氧化脂质的生成，且呈剂量依赖关系。提示黄芩甙有良好的抗氧化作用。

The antilipid peroxidation effects of Baicalin isolated from Scutellaria baicalensis Georgi.were Investigated.In vivo, po Baicalin at the dose of 25, 50 mg/kg/d×3 significantly inhibited the lipid peroxidation induced by the ip FeCl2-AA-ADP mixture and the inhibitory rates were75%and 84%respectively;In vitro,Baicalin also inhibited rat liver homegenate lipid peroxidation instimulated by FeCl2-AA and ADP-NADPH and the effects were dose-dependent. The Results demonstrated that Baicalin has strong antioxidation effects.