氟喹诺酮类抗菌剂氟罗沙星合成工艺研究

Studies on Synthesis of Fluoroquinolone Antimicrobial Agent Fleroxacin

氟罗沙星由２，３，４－三氟硝基苯经还原、缩合环合、氟乙基化、螯合、上甲基哌嗪、水解、精制等七步反应制得。反应条件温和，副反应少，总收率达４０％。

An improved synthesis of antibacterial agent fleroxacin,starting from 2,3,4-trifluoronitrobenzene via reduction,condensation-cyclization,fluoroethylation,chelation,piperazination,hydrolysis,etc,was described.The reactions of all steps were carried out under very mederate conditions with the overall yield of 40%.