手性铑（I）配合物催化的不对称环化反应

Asymmetric Cyclization Using Rhodium(I)with Chiral Ligand

在以ＢＩＮＡＰ为配位体的中性或阳离子铑配合物催化下，３，４－二取代－４－戊烯醛高立体选择性（＞９９％ｄ．ｅ．）地环化为对应的ｃｉｓ（或ｔｒａｎｓ）３，４－二取代环戊酮衍生物。阳离子铑配合物与中性铑配合物在不对称环化反应中给出相反构型的产物。

Highly diastereoselective cyclization (> 99%de) of 3R(or S)3,-disubetituted 4-pentenals into the corresponding 3,4-cis(or trans)-disubstituted cyclopentanone was achieved by using cationic RH +(BINAP) ClO4 or neutral RhCl (BINAP).The asymmetric cyclization using the cationic Rh-complex affords the reversed con figuration to the case of neutral rhodium.