呈米氏消除动力学特征药物半衰期的简便估计法

A simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics

目的:建立一个简便估算呈米氏消除动力学特征药物半衰期的方法.方法:呈米氏消除动力学特征的药物,其消除半衰期与血药浓度成线性关系.利用一次给药后的血药浓度—时间数据便能画出该直线的方法,结果与结论:直接从直线图上读出任意浓度的半衰期.该方法还可用来估计血药浓度下降任意分数所需时间.

AIM:To establish a simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics. METHODS: A linear relationship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple method is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection. RESULTS & CONCLUSION: The elimination half-life can be read from the regression line. The method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.