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纳洛酮通过加强压力反射抑制缺血性心律失常 被引量:2

Naloxone suppresses ischemic arrhythmias via potentiating foaroreflex
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摘要 目的研究纳洛酮(Nal)抗心律失常作用与其对压力反射敏感性(BRS)影响的关系.方法:以冠状动脉结扎法制备Sprague-Dewley大鼠急性心肌梗塞模型,心电图记录室性早搏(VE),室性心动过速(VT)和心室颤动(VF);静脉注射苯肾上腺素后同步记录的收缩压与心动周期变化的回归直线斜率(b)为BRS;TTC染色法评价梗死范围.结果:Nal 0.5 mg iv,小脑延髓池注射(ic)Nal 0.1mg和ic β-内啡肽(β-End)抗血清10 μL可抑制缺血性心律失常,心律失常积分为1.8±1.1(Nal iv)vs 3.8±2.1(生理盐水iv);1.7±1.5(Nal ic)vs 4.0±2.6(人工脑脊液ic)和1.7±1.6(β-End抗血清ic)vs4.1±2.0(血清ic)(P<0.05);并可加强BRS,BRS为4.2±1.8(Nal iv)vs 2.9±0.8(生理盐水iv);4.5±1.7(Nal ic)vs2.8±0.7(人工脑脊液ic)和4.4±1.1(β-End抗血清ic)vs3.0±0.9(血清ic)(P<0.05).BRS与心律失常积分呈负相关,r值分别为-0.69(Nal,iv);-0.72(Nal,ic)及-0.67(β-End抗血清.ic).P值均<0.05.结论:Nal通过拮抗中枢β-End及加强BRS起抗心律失常作用. AIM: To study the relationship between the anti-arrhythmia action of naloxone (Nal) and its effect on baroreflex sensitivity (BRS). METHODS: Acute myocardial infarction was produced by ligating coronary artery in Sprague-Dawley rats. Ventricular extrasystole ( VE ), tachycardia (VT ) , and fibrillation (VF) were recorded on ECG. The slopes of linear regression (b) from systolic blood pressure and cardiac cycle after intravenous injection (iv) of phenyiephrine 2 μg was taken as the BRS . The area of infarct was estimated after TTC staining. RESULTS: Nal 0. 5 mg iv. intracisternal injection (ic) of Nal 0.1 mg, and ic β-endorphin (β-End) antiserum 10μL suppressed the ischemic arrhythmias, arrhythmia score was 1. 8±1.1 (Nal iv) vs 3. 8 ±2.1 (Saline iv); 1. 7± 1. 5 (Nal ic) vs 4. 0 ±2. 6 (Artificial CSF ic) and 1. 7± 1. 6 (β-End antiserum ic) vs 4. 1±2. 0 (Serum ic) (P <0. 05) and potentiated the BRS, BRS was 4. 2±1. 8 (Nal iv) vs 2. 9±0. 8 (saline iv); 4. 5±1. 7 (Nal ic) vs 2. 8±0. 7 (Artificial CSF ic) and 4. 4±1.1 (β-End antiserum ic) vs 3.0 ±0.9 (Serum ic) (P<0. 05). BRS showednegative relations to the arrhythmia scores with r of - 0. 69 for iv Nal, -0. 72 for ic Nal, and - 0. 67 for ic β-End antiserum (P< 0.05). CONCLUSION: Nal suppressed ischemic arrhythmias via antagonization of beta-endorphin and potentiation of BRS.
出处 《中国药理学报》 CSCD 1995年第2期169-172,共4页 Acta Pharmacologica Sinica
关键词 纳洛酮 心律失常 压力感受器 内啡肽 naloxone pressoreceptors myocardial infarction beta-endorphin arrhythmia
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  • 1Wong T M,J Mol Cell Cardiol,1990年,22卷,1167页
  • 2Zhu Y X,第二军医大学学报,1986年,7卷,332页

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