摘要
用TBA法测定丙二醛(MDA)含量,观察金丝桃甙(Hyp)对阿霉素以及缺氧/再灌注所致心肌脂质过氧化的影响。结果表明:Hyg100mg·kg-1和EGTA400μmol·kg-1ip可明显抑制阿霉素所致小鼠心肌MDA含量的升高,HPP可增强EGTA的作用,A23187拮抗Hyp的作用。HyP10、100μmol·L-1可显著减少缺氧;再灌注离体大鼠心脏MDA的产生。提示Hyp具有抗心肌脂质过氧化的作用,此作用可能与其阻滞钙内流有关。
The effect of hyperin(Hyp) on adriamycin-and hypoxia/ reperfusion-induced myocardial lipid peroxidation was investigated using malondialdehyde (MDA) as an index. The increase in MDA in murine cardiac tissue after administration of adriamycun (15 mg·kg-1, ip) was significantly inhibited by Hyp 100 mg·kg-1 and EGTA 400 μmol·kg-1 ip. A23187 antagonized the effect of Hyp. Hyp enhanced the effect of EGTA. Also, Hyp 10, 100μmol· L-1 markedly reduced the increase in MDA production in isolated rat hearts after hypoxia/ reperfusion. The results suggest that Hyp possess an antiperoxidative activity, and this effect may be related to blocking calcium influx.(Now in Anhui Tunxi Second Pharmaceutical Factory,Huangshan 245011)
出处
《中国药理学通报》
CAS
CSCD
北大核心
1995年第2期123-125,共3页
Chinese Pharmacological Bulletin
关键词
金丝桃甙
脂质过氧化
心肌缺氧
再灌注损伤
hyperin
lipid peroxidation
malondialdehyde
adriamycin
myocardial reperfusion injury