国产洛美沙星的体内抗菌作用研究

The antibacterial activity of lomefloxacin in vivo

研究国产洛美沙星对３种致病菌感染的体内保护作用。小鼠灌胃洛美沙星对金黄色葡萄球菌感染的保护作用为诺氟沙星的３倍，环丙沙星的２倍；对大肠杆菌感染的保护作用是诺氟沙星的８倍，而略逊于环丙沙星；对绿脓杆菌的保护作用则是诺氟沙星的３～４倍，与环丙沙星相似或略差。小鼠静注洛美沙星亦表现明显的抗菌活性，并优于口服给药。结果显示，本品对３种细菌感染的保护作用明显优于诺氟沙星而具有良好的体内抗菌作用。

The antibacterial activity of LFLX in vivo was evaluated against 3 kinds of common bacteria isolated clinically and compared with the activities of NFLX and CPLX. In po groups, LFLX was about two times more active than NFLX and one time more active than CPLX against infections With S.aurens.The ED_(50) of LFLX against mice infected by S.aureus were 7.53,6.96mg·kg￣(-1),respectively, LFLX was about six and seven times more active than NFLX against infections with two strains of E.coil, respectively, but its activity was lower than that of CPLX against E. coil. The ED_(50) of LFLX against mice infected by E.coil were 0.78 and 0.50 mg·kg￣(-1), respectively. LFLX was about three times as active as NFLX against infections with two strains of Ps. aeruginosa. the activity of LFLX was similar to that of CPLX against one of two strains of P. aeruginosa, but lower than CPLX against another.The ED_(50) of LFLX against mice infected by Ps.aeruginosa were 9.05, 7.42 mg·kg￣(-1),respectively. This study suggest that LFLX is a very effective antimicrobial agent.