山莨菪碱，川芎嗪预防肺水肿时大鼠动脉血浆及支气管肺泡灌洗液中6－Keto－PGF1α和TXB2含量的变化

The effect of Anisodamine and Tetramethlpyrazine on the 6-Keto-PGF1α and TXB2 level of plasma and brinchoalveolar lavage fluidin rats with pulmonary edema

用肾上腺素所致肺水肿模拟临床上常见的神经源性肺水肿，如颅脑创伤，高原缺氧，脑血管病等所致肺水肿就属此类，具有动力性和非动力性双重机制，既有肺毛细血管压力升高，又有肺毛细血管通透性增高，大鼠在数分钟内迅速死亡．而从股静脉注射山莨菪成（３０ｍｇ·ｋｇ－１）和川芎嗪（１２０ｍｇ·Ｋｇ－１）进行预防，绝大部分动物均不形成肺水肿。为了探讨ＰＧＩ２与ＴＸＡ２在此模型中的作用，我们先后测定了用山莨菪碱和川芎嗪预防后大鼠颈动脉血和支气管肺泡灌洗液６－Ｋｅｔｏ－ＰＧＦ１α和ＴＸＢ２的含量变化，结果表明，山莨菪碱和川芎嗪能有效地降低血浆和支气管肺泡灌洗液的ＴＸＢ２含量（Ｐ＜０．０１），对６－Ｋｉｔｏ－ＰＧＦ１α无明显影响（Ｐ＜０．０５），推测山莨菪碱和川芎嗪在预防肺水肿的发生中，ＴＸＡ２参与动力学和非动力学机制来达到ＰＧＩ２与ＴＸＡ２的平衡。Ｐ＜０．０１速恢复，存活时间＞３０ｍｉｎ者３０ｍｉｎ时取血，收集支气管肺泡灌洗液（ＢＡＬＦ）；第四组为川芎嗪预防组，先于股静脉注射川芎嗪１２０ｍｇ·ｋｇ－１作为预防，再注射上述过量Ａｄｒ，动物经一度呼吸困难甚至暂停后迅速恢复，存活者注射Ａｄｒ后３０ｍｉｎ取血，收集ＢＡＬＦ。颈总动脉的血直接?

Pulmonary edema(PE)induced by adrenaline(Adr)administration in rats is similar to neurogenic pulmonary edema. Anisodamine(ADM,30mg·kg-1)and tetramethylpyrazine(TMP,120mg.kg-1)have shown apparent preventing effect on PE.In the 6-Keto-PGF1α and TXB2 levels in ADM and TMP preventive groups were measured of plasma and bronchoalveolar lavage fluid(BALF).The results showed that TXB2 levels in ADM and TMP preventive groups remarkly decreased in plasma and BALF(P < 0.01),but 6-Keto-PGF1αcontents were unchanged.It is suggested that ADM and TMP to adjust TXA2 levels may be one of the preventive mechanisms of these drugs.