松果体对正常及佐剂性关节炎大鼠免疫细胞的影响

Effects of pineal gland on immune cells in normal and adjuvant arthritis rats

采用松果体切除（ＰＸ）及腹腔注射外源性褪黑素（ＭＴ）的方法，观察松果体对正常及佐剂性关节炎（ＡＡ）大鼠免疫细胞的影响。结果发现，ＰＸ后，ＣｏｎＡ及ＬＰＳ诱导的淋巴细胞增殖反应在正常及ＡＡ大鼠明显降低；正常大鼠ＬＰＳ诱导的腹腔巨噬细胞产生的白细胞介素Ｉ（ＩＬ－１）减少，而ＡＡ大鼠的ＩＬ－１明显增加。ＭＴ（１０μｇ·ｋｇ－１）作用则与此相反，并能使ＰＸ引起的免疫指标的改变恢复正常。上述结果表明；松果体对免细胞的功能有调节作用。

The effects of pinealectomy and exogenous melatonin on immune cells of normal and adjuvant arthritis(AA) rats were investigated. It was found that PX could inhibit ConA and LPS-induced proliferation of splenocytes in normal and AA rats, and decrease LPS-induced IL-1 production of peritoneal macrophages in normal rats but showed counter-effects in AA rats.Exogenous MT(10μg kg-1)could antagonize above changes and restore to normal level, which suggested that pineal gland regulated the function of immunc cells in vivo.