噻拉嗪对小鼠大鼠抗缺氧的实验研究

Effects of xylazine on anoxia in rodents

采用常压缺氧，窒息性缺氧，组织缺氧等方法观察噻拉嗪对小鼠、大鼠缺氧的保护作用。结果表明，不同剂量的噻拉嗪均能延长小鼠常压缺氧的生存时间，降低耗氧量，提高动物对缺氧环境的耐受力，呈剂量依赖性关系。尤以噻拉嗪ｉｃｖ作用显著，并为α２受体拮抗剂苯恶唑阻断。此外噻拉嗪明显降低氰化钾中毒小鼠的死亡率，提高窒息性缺氧大鼠的氧分压，延长窒息性缺氧小鼠心电消失时间。

The effects of xylazine on anoxia at mice and rats were studied In methods of atmospheric anoxia,anoxic anoxia,histotoxic anoxia.The results indicate that xylazine protracted survival time,decreased the consumed oxygen and enhanced me endurance to anoxia at mice on atmospheric anoxia,especially by intracerebralventricule injection.The effects followed a dose-dependent manner and were reversed by idazoxan,a α2-adrenoceptor antagnoist.In addition,xylazine decreased obviously the mortality of mice on cyanide potassium poisoning,improve oxygen pressure in arterial blood and prolonged the duration of electrocardigram in auoxic mice or rats.