摘要
Ｎ＿ω一硝基一Ｌ一精氨酸甲基酯对电刺激毁脑脊髓大鼠交感神经诱发缩血管作用的影响金万宝，孙玉斌，关福兰（中国医科大学药理学教研室，沈阳１１０００１）Ｆｕｒｃｈｇｏｔｔ等［１］在１９８０年首次提出内皮细胞舒血管因子（ｅｎｄｏｔｈｅｌｉｕｍ－ｄｅｒｉｖｅｄ...
The effect of Nω-nitro-L-argininemethyl ester(L-NAM E),one of arginine analoguesand inhibitors of NO synthase,on pressor responseelicited by sympathetic nerve stimulation in the pit-hed rats was investigated.L-NAM E(1, 0,3.0,10.0mg·kg-1)significantly enhanced pressor response in-duced by sympathetic nerve stimulation with 1,4, 16Hz frequencv and the effect was dose-dependent.Itsuggests that norepinephrine released from sympathet-ic nerve tenninal could lead to the produce of NO inendothelial cells which mocdulate repressively thepressor response to sympathetic nerve stimulation.
出处
《中国药理学与毒理学杂志》
CSCD
北大核心
1995年第3期237-238,共2页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金
关键词
硝基
L-精氨酸甲基酯
交感神经
血管
内皮细胞
Nω-nitro-L-arginine methyl ester
NO synthase
pithedrat
sympathetic nerve
end othelium-derived relaxing factor Project supported by the National Natural ScienceFoundation of China
No 39270309
