7－氯苄基四氢巴马汀对豚鼠乳头肌迟后去极，触发活动及猫心单相动作电位的影响

Effects of 7-chlor-benzyltetrahydropalmatine on delayed after depolarization,triggered activity in guinea pig papillary muscle and monophasic action potential in cat heart

７一氯苄基四氢巴马汀对豚鼠乳头肌迟后去极，触发活动及猫心单相动作电位的影响夏国瑾，曾维忠，姚伟星，戴水平，江明性，黄文龙，黄忱亚，彭司勋（同济医科大学药理学教研室，武汉４３００３０；中国药科大学药物化学研究室，南京２１０００９）７－氯苄基四氢巴马汀（...

The study by usjng standardmicroelectrode techniq ues in guinea pig papillary muscle in-dicated that ouabain-induced delayed a fter-depolariza tionand triggered acti vity were abolished by 7-chlor-benzyl-tetrahydropalmatine(7-chlor-BTHP)50 μmol·L-1. Anoth-er study showed that 7-chlor-BTHP prolonged monophasicAPD50 and APD90 from 222 ±20 and 314 ± 54 ms to 264±28 and 334 ± 54 ms(x±s, P< 0.05,n=5)respectivelyin normal myocardium of cat.In the meantime,the short-ened APD induccd by iscbemia and reperfusion was res-stored to normal level by 7-chlor-BTHP. 7-Chlor-BTHPdecreased monophasic action potential amplotude and heartrate from 55 ± 7 mV and 62 ± 8 beats· min-1 to 44±10mV and 57 ± 9 beats·min-1(x±s, P<0. 05,n=5)respectively.It also decreased incidences of vendcularfibrillation and mortality and could prothect againstmyocardial damagc caused by ischemia and reperfusion.