环匹阿尼酸对一氧化氮、硝普纳和8－溴鸟苷环一磷酸松弛家兔主动脉作用的影响

Effect of cyclopiazonic acid on aortic relaxation induced byNO,nitroprusside sodium and 8-bromo-cGMP in rabbits

环匹阿尼酸对一氧化氮、硝普纳和８－溴鸟苷环一磷酸松弛家兔主动脉作用的影响罗大力，杨宝峰，李光泽（哈尔滨医科大学药理教研室，哈尔滨１５００８６）硝酸酯类血管扩张剂对心绞痛和顽固性心衰等疾病的治疗发挥十分重要的作用。其松弛血管平滑肌的机理与内源性血管平滑...

The mechanism of arterial relaxationinduced by cyclic GMP-generators was studied inrabbit aortic rings by using cyclopiazonic acid (CPA),aselective inhibitor of sarcoplasmic reticulum(SR)Ca2+-pump.CPA 30 μmol·L-1 inhibited therelaxing effects of nitric oxide(NO).nitroprussidesodium(NPS)and 8-bromo-cGMP on the aorticrings contracted by 1 μmol·L-1 phenylephrine,andthe percentages of the maximal inhibition by CPA inthe above three groups were 45%,43% and 23%respectively.In conclusion,the result further indicatedthat the enhanced activity of SR Ca2+-pump might beone of the important mechanisms for the aortic relaxa-tion induced by cGMP-generators in rabbits.