新型血管紧张素转化酶抑制剂Enalapril的合成研究

Studies on Synthesis of Enalapril,A New Angiotensinconverting Enzyme Inhibitor

本文报道了以苯和顺丁烯二酸酐为起始原料合成新型血管紧张素转化酶抑制剂Ｅｎａｌａｐｒｉｌ的新合成方法，总收率为１６．２％；此路线无特殊设备及试剂要求，具有ＳＳ－构型的（４）非对映异构体在无水乙醇中溶解度小，沉淀析出，而使（４）的ＳＳ－构型和ＲＳ－构型的两个非对映异构体分开。

Enalapril, a new kind of angiotensinconverting enzyme inhibitor,was synthesized by a novel synthetic method. The total yield was 16.2%, There was no special equipment and reagent to be used in the process, Because the diastereomer(4)with SS-configuration was only slightly soluble in ethanol and precipitated out of the solution,two diastereomers of compound(4)were separated.