左旋肉毒碱盐酸盐新的合成方法（Ⅱ）

A New Synthesis and Resolution of Carnitine Hydrochloride

以氯乙酸乙酯为起始原料，经过格氏反应、还原、铵化、水解及拆分等五步反应，合成了左旋肉毒碱盐酸盐。优点是避开有毒的氰化物或氯化汞，且无需离子交换树脂．操作安全、简单。

l-Carnitine hydrochloride was synthesized primarily from chloroethyl acetate via the Grignard reaction,reducton,amination, hydrolysis and resolution. The dibenzoyl-d-tartaric acid was used as a resolutive agent. By this method,a poisonous cyanide or mercuric chloride could be avoided ,and basic ion-exchange resin could be avoided, too.