摘要
体外实验发现,双嘧达莫(DP),10ug/ml单独作用于人白血病细胞(HL-60细胞),不能引起活细胞计数明显减少;DP与鬼臼乙叉甙(VV-16)联合作用于HL-60细胞,活细胞计数较单用VP-16时明显降低。家兔体内实验表明,DP不能明显改变VP-16的药代动力学参数;DP有可能对VP-16的代谢方式有微弱的影响。本实验结果提示,DP在体内有可能在不明显影响VP-16体内过程的条件下增强其抗肿瘤的作用。
In vitro,the effect of dipyridamole(DP )and etoposide(VP-16 )on humanleukemia-60(HL )cells was examined by trypan blue exclusion. It was found that DP had not cy-tocidal effect on the cells ,and there were significantly fewer viable cells in the case of concomitantexposure to DP and VP-16 than in the case of only exposure to VP-16.In vivo,the pharma-cokinetics of VP-16 was studied in rabbits by determining the concentration of VP-16 in serum byHPLC. It was known that DP could not significantly change the pharmacokinetic parameters ofVP-16,and DP had slight effect on the metabolic manners of VP-16.The results indicate that DP,in vivo,might augment the antitumor activity of VP-16 without obvious action on its pharma-cokinetics.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1995年第1期16-19,共4页
Chinese Pharmaceutical Journal