胰岛素经眼吸收后对正常和四氧嘧啶致糖尿病模型家兔的降血糖作用

Reduction of blood sugar levels with insulin eyedropks in normal andalloxan-treated diabetic rabbits

国产胰岛素（生化提取法）经眼吸收后能有效地降低正常和四氧嘧啶糖尿病模型家兔血糖。研究结果表明，胰岛素经眼给药后，能有效地降低两者的血糖浓度。用１％ＥＤＴＡ溶液为吸收促进剂，给正常家兔０．５％和１．０％胰岛素５０ｕｌ后，在１５ｍｉｎ即能发挥作用，维持低血糖状态５ｈ以上。给予糖尿病模型家兔１％和２％胰岛素５０ｕｌ后，在３０ｍｉｎ起效，可使血糖降至常范围内，药物疗效维持５ｈ以上。不加１％ＥＤＴＡ溶液的胰岛素作用明显减小。在０．５％～２．０％的剂量范围内吸收不存在饱和现象，而作用效果存在着浓度依赖性。

The reduction of blood sugar levels of insulin eyedrops was studied in normal andalloxan-treated diabetic rabbits. The glucose concentration was reduced after use of 1%and 2%insulin eyedrops cornpared with 1%and 2%insulin with 1%EDTA, The blood glucose levelswere decreased 15 min after administration , and maintained for 5 hours. A significant reductionwas obsevered after the use of 1%EDTAas a absorbed enhancer.