抗癌生物碱安托芬的Hofmann降解

Hofmann degradation of antofine,an antileukemia active alkaloid

安托芬（ａｎｔｏｆｉｎｅ）为一具有强抗白血病活性的生物碱。在研究国产天然抗癌活性成分安托芬的结构改造过程中，发现了新的霍夫曼降解反应。所生成的新降解产物（３）以体外抑瘤试验，结果表明具有较强的活性。

We studied Hofmann degradation of antileukemia active compound antofine(1),which afforded a new compound isoantofine methine(3).The compound(3) was demonstrated tohave significant antileukemia activity in vitro. The reaction mechanism was suggested.