吡罗昔康透皮给药制剂的人体生物利用度研究

Bioavailability of piroxicam transdermal preparations in human volun-teers

用反相高效液相色谱法测定血清中吡罗昔康浓度，并对２种透皮给药制剂进行了生物利用度比较，以此评价处方因素对药物在皮吸收的影响。结果表明，药物在制剂中的分散状态对其透皮吸收影响较大，溶解状态分散的药物易于透皮吸收。此外，透皮促进剂对药物的吸收也有一定影响。

Human bioavailability studies on two transdermal preparations of piroxicam weremade by determining serum concentration using HPLC,The effects of formulation factors ontransdermal absorption of piroxicam were observed.The results revealed that the effect of dis-persed condition of drug on transdermal absorption was higher. The transdermal absorption ofdissolved drug was easier than that of the drug powder. Otherwise,the enhancer had effect ontransdermal absorption of piroxicam.