摘要
头结海绵(Tylotellasp.)为我国青岛湾海域内新发现的一种海绵。对该海绵的化学成分进行了研究,分离出6种成分,根据理化性质和光谱数据,确定它们为:24-去甲-胆甾-5,22E-双烯-3β-醇、麦角甾-5,24(28)-双烯-3β-醇、胆甾醇、穿贝海绵甾醇、胸腺嘧啶脱氧核苷、酪胺。其中,胸腺嘧啶脱氧核苷具有多种药理活性,从海外中首次分得。
The sponge Tylotella sp.was newly discovered in Qingdao bay,China. We studied its chemical constituents for the first time. Six compounds were isolated from it by means of ex-traction of solvents and repeated normal,reverse chromatography. On the basis of physical,chemi-cal properties and spectroscopic data,the compounds were identified as:24-nor-cholesta-5,22E-di-en-3β-ol,ergosta-5,24 (28)-dien-3β-ol,cholesterol,24S-stigmast-5-en-3β-ol(clionasterol ),thymi-dine and tyramine. Among them,thymidine is a kind of nucleosides that has many pharmacological actvities.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1995年第9期524-526,共3页
Chinese Pharmaceutical Journal
基金
国家自然科学基金