中坝鹅掌叶附子中的生物碱研究Ⅰ

AlKaloids of cultivated Aconitum carmichaeli Ⅰ

从中坝（今名江油）３种栽培附于（ＡｃｏｎｉｔｕｍｃａｒｍｉｃｈａｅｌｉＤｅｂｘ．）之一的鹅掌叶附子中，分得１０种生物碱化合物，经几种光谱分析鉴定，证明其中２种为已知生物碱次乌头碱（ｈｙｐａｃｏｎｉｔｉｎｅ）和新乌头碱（ｍｅｓａｃｏｎｉｔｉｎｅ），还获得一种为新化合物，Ｎ－ＣＨＯＣ＿（１９）－二枯生物碱，命名为ａｌｄｏｈｙｐａｃｏｎｉｔｉｎｅ，后者再由ｈｙｐａｃｏｎｉｔｉｎｅ经氧化合成确证。

A new C_(19)-diterpenoid alkaloid,named aldohypaconitine(1) , was isolated from thelateral roots of O-Zhangye aconite(cultivated Aconitum carmichaeli)from Zhongba. The structureof the new alkaloid has been established by the use of carbon- 13 and proton NMR spectroscopy.Subesquently,this structure was confirmed by chemical correlation with known compound hypa-conitine. This is the first time that aldohypaconitine(1),an aconitine type N-CHO-diterpenoid al-kaloid,has been found in this plant. Along with this new alkaloid the known alkaloids,hypaconi-tine and mesaconitine were also isolated and characterized.