5－氟尿嘧啶肝素钠－白蛋白毫微粒的研究

Study of 5-FU heparin-albumin nanoparticles

采用乳液固化法制备了肝素钠－牛血清白蛋白毫微粒，并以口服给药的形式，研究毫微粒的肝靶向性。透射电子显微镜测定毫微粒的平均粒径为１８４±３１ｎｍ（ｎ＝３００）。以５－氟尿嘧啶为模型药物，将５－氟尿嘧啶肝素钠－白蛋白毫微粒在酸性条件下１００℃水解２０ｈ，测得５－氟尿嘧啶的平均包封率为２９．５％。体外试验结果表明，５－氟尿嘧啶毫微粒在３７℃的稀盐酸液中７２ｈ累计释药达７９．４８％。

Fluorourail nanoparticle was prepared by emusion method, heparin and albuminbeing chosen as carrier. The particle size distribution was measured and the arithmetic mean diam-eter was 184±31 nm(n=300). The encapsulation efficiency of the 5-FU nanoparticle was deter-mined with the result of 29.5%within 72 hours up to 79%drug release was observed from hep-arin-albumin nanoparticles.