摘要
随机将７０例行剖宫产产妇分为氨茶碱组４０例（宫内窘迫１０例、无窘迫３０例），对照组３０例（宫内窘迫８例、无窘迫２２例）；通过ｉｖ氨茶碱成功地降低了新生儿窒息率，提高Ａｐｇａｒ’ｓ评分值：前组（ｎ＝４０）均未发生窒息，后组窒息率分别为８７．５０％（ｎ＝７／８）及９．０９％（ｎ＝２／２２，Ｐ＜０．０１）；Ａｐｇａｒ’ｓ评分前组为９．６５×０．５３（ｎ＝４０），后组为６．００±２．７２（ｎ＝８）及８．８２±１．０１（ｎ＝２２，Ｐ＜０．０１）；脐动静脉血气分析显示茶碱能明显改善窘迫儿的缺氧及酸中毒症状（Ｐ＜０．０５～０．０１）；Ｂ超提示茶碱未增加胎儿宫内呼吸危险性；注药至胎儿娩出时间为１２．８８±４．６２ｍｉｎ，娩出时母血茶碱浓度３．２４±０．８３μｇ／ｍｌ，胎血５．４４±１．４６μｇ／ｍｌ（ｎ＝２４），术中及术后２４ｈ随访未见明显不良反应。
The safety and effectiveness of
theophylline through maternal transfer were studiedwith cesarean
section, 70 cesarean parturients were randomly allocated into two
groups:amino-phylline group(40) :intrauterine distress,10 and
nondistress,30 and control group(30):distress,8and nondistress, 22.
The asphyxiant rate was decreased while Apgar’s score was increased
suc-cessfully by intravenous injection of aminophylline.In the
aminophylline group,no suffocation oc-curred and Apgar’s score was
9. 65±0.53(n=40) but in the control group,the asphyxiant ratewas 87.
50%(n=8)and 9.09%(n=22,P<0. 01) and Apgar’s score was 6. 00±2.
72(n=8)and8. 82±1.01(n=22) respectively(P<0.01).Blood gas analysis
of umbilical arteries and veins in-dicated that aminophylline
significantly improved anoxia and acidosis of distress fetus(P<0.
05～0. 01 ).B ultrasonography marked aminophylline didn’t increase
the hazard of intrauterine respira-tion.The dynamic changes of
theophylline concentration within 45 min after administration
wereobserved. The time from administration to delivery was 12. 88±4.
62 min, Theophylline concen-trations of maternal and umbilical veins
at delivery were 3. 24±0. 83 and 5. 44±1, 46μg/ml re-spectively.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1995年第12期730-732,共3页
Chinese Pharmaceutical Journal
