高氟区青少年血清25－羟维生素D水平对骨龄延迟的影响

An Analysis of the Changes in Serum 25-Hydroxyvitamin D in Adolescents with Skeletal Age Retardation in High-Fluoride Arta

本文调查了６１名高氟区和４８名非高氟区７～１８岁青少年的骨龄，并测定了骨龄正常组和延迟组血清２５－羟维生素Ｄ（２５－ＯＨＤ）及血清钙、磷水平。结果发现，高氟区青少年骨龄延迟率显著高于非高氟区；高氟区骨龄延迟组的血清２５－ＯＨＤ水平显著低于该地骨龄正常组；高氟区２５－ＯＨＤ的水平低于非高氟区。提示，高氟区青少年骨龄延迟与血清２５－ＯＨＤ水平低有关。

e conducted a cross-sectional study of serum 25-hydroxymitamin D(25-OH D) level in 61 adoles-cents aged 7 18 yr,in an area of endemic fluorosis at a village in Inner-mongolia,while 48 adolescentsin a normal area nearby were also investigated.All adolescents were divided into two groups:skeletalage retardation group and normal skeletal group.The concentrations of serum fluoride, calcium andphosphorus were measured.The results showed that the levels of serum 25-OH D in the former groupwere significantly lower than that in the later in both areas(P<0.05).The levels of serum 25-OH Dand calcium in adolescents living in high-fluoride area showed markedly lower than that in normal area(P<0. 05,P<0.01).In normal skeletal age group,the serum calcium level in high fluoride area( P<0. 01).There was no statistic difference in serum calcium level between skeletal retardation groups inthese two areas. No difference was found in serum phosphorus levels between these two areas andgroups. No correlation was observed between levels of serum fluoride ,calcium and 25-OH D in both ar-eas. These results suggested that bone growth and development was delayed and the lower level ofserum 25-OH D might be related to the skeletal age retardation in adolescents living high-fluoride area.It is still unclear how high fluoeied intake influences the metabolism of vitamin D in adolescents.