博莱霉素致大鼠肺纤维化肺泡巨噬细胞氧化和抗氧化损伤的动态研究

Consecutive Study on Lipid Peroxidation of Alveolar Macrophage in Bleomycin-induced Pulmonary Fibrosis in Rats

动态观察了博莱霉素（ＢＬＭ）致大鼠肺纤维化过程中巨噬细胞氧化和抗氧化损伤的变化。结果表明：ＢＬＭ气管内灌注后肺泡巨噬细胞（ＡＭ）中ＭＤＡ含量第一天即明显增高，第三天达高峰，并明显高于对照组。同时，ＧＳＨ－Ｐｘ含量极低，于１４天、２８天逐渐上升始接近正常水平。认为ＡＭ脂质过氧化损伤在肺纤维化形成中发挥一定作用。

onsecutive study on lipid peroxidation of alveolar macrophage(AM ) was made in bleomycin-in-duced pulmonary fibrosis in rats.The results showed that AM MDA content was increased significantlyon day 1, and peaked on day 3 after the intratracheal instillation of bleomycin. Simultaneously,AMGSH-Px content was decreased significantly, and elevated gradually to normal level on day 14,28.Itwasconcluded that AM peroxidation might play a role in the development of pulmonary fibrosis, its re-lation with AM cytokines release remained to be clarified.