内皮素在原发性高血压发病中意义的探讨

Studies on the Role of Endothelin in Essential Hypertension

用放射免疫分析法测定了５６例原发性高血压患者血浆内皮素（ＥＴ）水平，并同时测定了血管紧张素Ⅱ（ＡⅡ）和心钠素（ＡＮＦ）的血浆水平，以探讨ＥＴ、ＡⅡ和ＡＮＦ在原发性高血压发病中的作用。结果，原发性高血压患者血浆ＥＴ、ＡⅡ及ＡＮＦ水平比对照组明显升高。而且，随着高血压病病情的发展，ＥＴ水平逐渐升高；ＥＴ水平的增高与ＡⅡ和ＡＮＦ水平增高呈正相关。用转换酶抑制剂依那普利治疗，三者水平均明显下降。推断高血压病的发生和进展与血浆ＥＴ水平增高有关，并通过ＡⅡ和ＡＮＦ进一步影响高血压病病情的进展。使用转换酶抑制剂引起的血压下降可能与血浆ＥＴ含量减少及ＡⅡ和ＡＮＦ含量同时减少有关。

e measured plasma immunoreactive concentration(PIC ) of endothelin (ET)in patients with es-sential hypertension, and at the sametime measured the PIC of angiotensin Ⅱ(A Ⅱ) and atrial natriuret-ic factor(ANF), in order to find some relationship between ET,AⅡand ANF in essential hyperten-sion. The results showed that the PIC of ET,AⅡ and ANF of patients group were higher than those ofcontrol group. For different grade hypertension petients, the more severe the condition was, the higherthe PlC of ET was. The PIC of ET in hypertension patients showed positive correlation with that of AⅡand ANF. For antihypertension group,the PIC of ET,A Ⅱ and ANF after treatment were much low-er than those before treatment. All these results suggested that there was strongly association betweenhypertension and PIC of ET, and through the correlation with AⅡand ANF, ET makes more effect onthe development of hypertension.