摘要
将大学生244名血清感染指标均阴性者随机分为3组,分别接种三步灭活和加热灭活疫苗,并设对照组,进行二年的免疫效果的对比观察。结果两疫笛水平一致。首免后7个月(全程免疫后),前者抗-HBs阳转率为89;7%,几何平均滴度549.69mIU/ml。后者不同批号抗-HBs阳转率各为100%和93.3%,14μg组显著高于前者同剂量组外,1、2年均无差异。几何平均滴度各为566.05和601.07mIU/ml。1、2年结果两疫苗也无显著差异。免后7个月的保护率前者为91.5%,后者为88.6%,也无显著差异。两种疫苗的反应均较轻微。
n this study,244 students with negative markers of
hepatitis B virus were divided into 3 groupsand inoculated with the
3-step inactivated and heat-inactivated hepatitis B vaccines
respectively. The re-sults showed that there was no statistical
significace between two groups in aspects of immunogenicityand
safety. At the 7th month after the first injection, the
seroconversion rate and the GMTof the firstgroup were 89.7%and 549.
69mlU/ml respectively, and those indicatorsof the second group were
from100%to 93.3%and from 566. 05mlU/ml to 601. 07mlU/m The protection
rates of two groups at the7th month after the first injection were
91.3%and 88.6%.
出处
《中国医科大学学报》
CAS
CSCD
1995年第3期266-269,共4页
Journal of China Medical University
基金
国家"八五"攻关课题
关键词
乙型肝炎疫苗
疫苗
免疫原性
安全性
heat-inactivited hepatitis B vaccine
3-step-inactivated hepatitis B vaccine
immuno-genicity
safety