慢性阻塞性肺疾病和肺心病急性加重期sIL－2R的研究

Research of Soluble Interleukin-2 Receptors in COPD and Cor Pulmonale Exacerbation

应用双抗体夹心ＥＬＩＳＡ法测定３２例慢性阻塞性肺疾病（ＣＯＰＤ）、３０例慢性肺心病急性加重期患者和３０例健康人血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）。结果：健康人血清ｓＩＬ－２Ｒ平均值为３１４．８±７１．９ｕ／ｍｌ。ＣＯＰＤ组和肺心病组血清ｓＩＬ－２Ｒ平均伍分别为５８２．４±２８５．９ｕ／ｍｌ、７９３．２±４７６．３ｕ／ｍｌ，明显高于健康对照组（Ｐ＜０．００１）。ＣＯＰＤ和肺心病组间比较结果：肺心病组明显高于ＣＯＰＤ组（Ｐ＜０．０５）。

ouble antibody sandwich enzyme-linked immunosorbent assay (ELISA ) was used for detectingserum soluble interleukin-2 receptors(sIL-2R)in 32 patients with COPD, 30 patients with cor pul-monale with exacerbation and 30 heathy persons, The resuts showed that the value in the healthygroup was 314. 8±71.9u/ml,having nothing to do with ages. The values of COPD and cor pulmonalegroups were 582. 4±285. 9u/ml and 793. 2±476. 3u/ml respectively,significantly higher than the con-trol group(P<0. 001 );also,the values of cases with cor pulmonale were significantly higher thanthose with COPD(P<0. 05)。