摘要
采用2-巯基乙醇还原抗人结肠癌单抗CMU15行 ̄(99m)Tc直接标记法标记,标记后CMU15免疫活性保持良好,标记率为96%。载瘤裸鼠腹腔注入24h后,标记单抗在肿瘤内有较高的选择性浓聚,γ照相肿瘤清晰显示,对照组无选择性分布,提示 ̄(99m)Tc-CMU15在肿瘤组织中有较好的特异性浓聚。
mmunoactivity remained well after labeled with
method of 2-mercaptothanol reduction-mediatedand Tc-99m direct
labeling,having high labeling efficiencies(96%).24 hours later after
injection ofCMU 15 through I.P,there were higher selective
concentration of labeled monoclonal antibody in thetumor and clear
visulization of tumor ,indicating that Tc-99m CMU 15 can specifically
concentrate inthe tumor.
出处
《中国医科大学学报》
CAS
CSCD
1995年第4期398-400,共3页
Journal of China Medical University