特发性肺纤维化患者支气管─肺泡灌洗液促凝活性测定及临床意义

The Determination of Procoagulant Activity in Bronchoalveolar lavage Fluid with Interstitial Pulmonery Fibrosis and Its Significance

应用复钙法测定１８例特发性肺纤维化（研究组）和１２例无肺疾病健康人（对照组）的支气管─肺泡灌洗液促凝活性。结果显示，研究组的促凝活性明显高于对照组（Ｐ＜０．０１）。相关分析表明，支气管─肺泡灌洗液中促凝活性与巨噬细胞有一定相关性（ｒ＝０．４５６，Ｐ＜０．０５）。提示在间质性肺疾病患者肺内可能存在着促凝活性亢进。这种亢进对间质纤维化的形成和发展可能有一定影响。

he procoagulant activity (PCA)in bronchoalveolar lavage fluid(BALF)were measured in 18 pa- tients with interstitial pulmonary fibrosis(IPF)as a studied group and in 12 healthy persons as a con-trol by means of recalcified time. The results showed that the PCA in the studied group was higher thanthat in the control group(P<0.01). Negative correlation existed between PCA and macrophagecounts in BALF(r=-0.456,P<0.05). The results suggested that there might be hypercoagulantactivity in the patients with interstitial lung disease. The hyperactivity might exert influence on the for- mation and development of interstitial fibrosis.