摘要
电镜观察表明，锌酞菁人血清低密度脂蛋白（ＬＤＬ）复合物对小鼠ＭＳ－２纤维肉瘤细胞有很强的直接光敏杀伤作用，瘤细胞出现一系列结构改变：核染色质凝聚、局部核膜孔消失、核固缩、核破裂、凝聚的染色质流散、胞质内吞噬现象、胞膜表面肿胀粗钝的胞突形成、细胞碎裂等。提示该复合物光敏作用可诱导肿瘤细胞的程序性死亡，为解释其光敏杀伤机理提供了新的论据。
Phthalocyanine destruction of MS-2 fibrosarcoma cells in mice induced by LDL-administered Zinc-phthalocyanine and red light irradiation was studied by electron microscopy.The pronounced structural changes such as chromatin condensation,disappearance of nuclear pores,karyopyknosis,karyorrhexis,leakage of chromatin aggregates,autophagocytosis, bleb formation on the cell surface, cytoplasmic vacuolization and cell fragmentation suggest that the tumor cell death was induced by apoptosis.However,its exact mechanism and regulating pathways remain to be further investigated.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1995年第1期25-29,共5页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金
关键词
锌酞菁
光化学疗法
纤维肉瘤
zinc-phthalocyanine
photochemotherapy
fibrosarcoma
