新生兔急性缺氧的实验研究

Experimental Study on Acute Hypoxia in Newborn Rabbits

新生兔急性缺氧的实验研究王丹华，张宏，孙仁宇，徐景蓁，张苏平（中国医学科学院，中国协和医科大学协和医院，北京１００７３０）为研究围产期窒息时的缺氧缺血性损伤，本实验建立了新生兔急性缺氧模型，并着重观察川芎嗪及山茛菪碱（６５４－２）对缺氧新生兔的肺动脉...

Abstract To investigate the hypoxic-ischemic damage of perinatal asphxia, the acute hypoxic models of newborn rabbits were established and the effects of ligustrazine and anisodamine on pulmonary arterial pressure(PAP),dural blood flow(DBF)and blood gas of the hypoxia rabbits were observed. Acute hypoxia was caused by inhalation of 10%O_2+90%N_2 mixture.PaO_2 was obviously reduced.PAP and DBF were obviously increased. But PAP in ligustrazine group did not increase and the elevated level of PAP in the anisodamine group was lower than the control.DBF and PaO_2 was not affected by using both of the drugs.Ligustrazine and anisodamine might he effective for preventing and treating newborn perisistent pulmonary hypertension.