摘要
本文观察了15%体表面积Ⅲ度烧伤后家兔血清锌的变化与血清蛋白及碱性磷酸酶的关系。烧伤后血清锌即显著下降,后逐渐恢复。血清碱性磷酸酶的变化与血清锌相似,两者呈高度正相关。血清蛋白显著降低,烧伤后第15天仍未恢复,其变化亦与血清锌呈正相关。表明锌与蛋白合成有关,提示血清碱性磷酸酶可作为烧伤后低锌血症的诊断及补锌效果的观察指标。
We report herein the correlation of changes in serum zinc with serum proteins,serum alkaline phosphatase (AKP) activity and body weight in 15% TBSA Ⅲ' burned rabbits., Serum zinc concentration reduced immediately from 181.4 to 112.4 ug/dl, then gradually increased and finally approached normal on 15 postburn day. Similar changes were found in serum AKP activity.AKP activity in the burned group was much lower than that in the control group.Total serum protein and albumin contents were significantly reduced and was not recovered to normal levels on 15 postburn day. Serum albumin/globulin decreased btu without a turnover. Body weight dropped to a minimum on 9 postburn day and was recovered on 15 postburn day. These results reveal a correlation of serum zinc concentration with serum protein, suggesting that zinc is closely related to protein synthesis. We conclude that serum AKP activity could be used as a diagnostic criterion of postburn hypozincemia as well as an index to assess the effectiveness of supplmental zinc in burns.
