干细胞移植治疗阿尔茨海默病的研究进展

Progress in stem cell therapy for Alzheimer's disease

干细胞移植可能足未来治疗阿尔茨海默病(AD)的可行性方法之一,许多动物实验都证实干细胞移植能改善记忆和认知功能;然而AD的病理改变,如B淀粉样蛋白(Aβ)沉积等对干细胞的存活和分化有不利影响.通过转染肾胰岛素残基溶酶于干细胞或使用苯羟基丙氨酸可减弱这些不利影响.增强干细胞表达神经营养因子不仅能减弱AD病理改变对干细胞的不良影响.更对脑内原有神经元起到保护作用.进一步研究如何减弱AD病理改变对干细胞的不良影响,充分发挥干细胞的治疗作用对将干细胞移植应用于临床具有重大意义.

Stem ceils transplantation is one of the potential therapeutic strategies for Alzheimer's disease (AD). Many animal models following stem cell transplantation showed improvement in memory and cognitive function. However, the pathological changes in AD, such as arnyloid beta deposits, negatively affect the survival and differentiaition of stem cells. Stem cells transfectcd with neprilysin or administration of phenserine could at-tenuate these adverse effects. Genetic modification of stem cell by over expression of neurotrophic factors could attenuate the adverse effects not only on stem cells but also on degenerative neurons. Further investigation on how to overcome the adverse effects of phathological factors in AD on stem cells and maximize the therapeutic effects of stem cells would support the hope for introduction of stem cells transplation into clinical application.