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老年高血压病合并射血分数正常的心力衰竭患者血浆脑钠肽水平的变化及药物干预 被引量:1

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摘要 目的 探讨老年高血压病合并射血分数正常的心力衰竭(HF-NEF)患者血浆脑钠肽(BNP)水平的变化以及缬沙坦(代文)对其心功能的影响.方法 测定40例老年高血压病合并HF-NEF患者(心力衰竭组)和30例高血压病心功能正常的老年患者(对照组)血浆BNP水平和心脏彩超多项指标.将40例心力衰竭患者随机分为常规治疗组20例和代文治疗组20例,治疗前后对比血浆BNP水平及心脏彩超多项指标.结果 老年高血压病合并HF-NEF患者血浆BNP浓度显著高于对照组(P<0.01),且随着NYHA心功能分级程度的加重而显著增高(P<0.01).治疗6个月后,代文治疗组血浆BNP水平以及反映左室形态和舒张功能的指标明显改善(P<0.05).临床疗效评定总有效率为90%,与常规治疗组比较差异有统计学意义(P<0.05).结论 老年高血压病合HF-NEF患者血浆BNP水平随心力衰竭严重程度的加重而显著升高,代文可以改善左室舒张功能,血浆BNP水平对诊断老年高血压病合并HF-NEF及评价疗效有重要作用.
作者 罗世红 贾玲
出处 《中国实用医刊》 2010年第4期51-52,共2页 Chinese Journal of Practical Medicine
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