中性粒细胞明胶酶相关蛋白及基质金属蛋白酶10在非小细胞肺癌中的表达及临床意义

The expression and clinical significance of NGAL and MMP-10 in non-small cell lung cancer

目的 观察中性粒细胞明胶酶相关蛋白(NGAL)和基质金属蛋白酶10(MMP-10)在非小细胞肺癌(NSCLC)中的表达,探讨其与NSCLC浸润、转移的关系.方法 采用免疫组织化学SP法检测70例非小细胞肺癌组织及30例癌旁肺组织标本中NGAL和MMP-10的表达,并分析它们的表达与相关临床参数的关系.结果 NSCLC组织中NGAL和MMP-10的表达分别为67.1%、70.0%,并与肿瘤直径、TNM分期、淋巴结转移明显相关(P<0.05),而与患者性别、年龄无关.NGAL和MMP-10的表达呈正相关(r=0.376,P=0.001).结论 NSCLC组织中NGAL和MMP-10表达明显增加.NGAL和MMP-10可能在NSCLC的发生、发展中起一定作用.

Objective To observe the expression of neutrophil gelatinase associated lipocalin (NGAL) and matrix metalloproteinase 10(MMP10) in human non-small cell lung cancer(NSCLC) and to investigate their correlations with the infiltration and metastasis of NSCLC.Methods Immunohistochemistry method was applied to investigate the expression of NGAL and MMP-10 in specimens of 70 NSCLC tissues and 30 paracancerous tissues.The relationship between the expression of NGAL and MMP-10 in the NSCLC tissue and related clinical parameters were analyzed. Results The positive expression rates of NGAL and MMP-10 in NSCLC tissues were 67.1% and 70.0%,respectively. The expression of NGAL and MMP-10 in NSCLC tissues was correlated with the diameter of the mass, the pathological grading, the lymph node metastasis, but not correlated with sex, age and smoking. There was a positive correlation between NGAL and MMP-10 expression in lung squamous cell cancer tissues (r=0.376, P=0.001).Conclusions Higher expression of NGAL and MMP-10 may play an important role in carcinogenesis and development of NSCLC.