高迁移率蛋白B1和血管内皮生长因子在人食管鳞状细胞癌组织中的表达及意义

Expression and significance of HMGB1 and VEGF in esophagus squamous cell carcinoma

目的 探讨高迁移率蛋白B1(HMGB1)和血管内皮生长因子(VEGF)在人食管鳞状细胞癌组织中的表达及临床意义.方法 选择51例食管鳞状细胞癌标本,应用SP免疫组织化学染色法,检测HMGB1和VEGF在人食管鳞状细胞癌组织中的表达,并与临床病理参数的关系进行统计学分析.结果 食管鳞状细胞癌组织中HMGB1、VEGF的表达显著高于正常组织(P<0.05),且与淋巴转移相关(P<0.05),与肿瘤大小、分化程度等无相关性,食管鳞癌中HMGB1与VEGF的表达呈正相关(r=0.476,P<0.05).结论 HMGB1和VEGF的表达与食管癌患者的淋巴结转移相关,可作为判断预后的观测指标.

Objective To investigate the expression and clinicopathological significance of high mobility group box 1 (HMGB1) and vascular endothelial growth factor (VEGF) in esophagus squamous cell carcinoma. Methods The immunohistochemical S-P method was used to detect the expressions of HMGB1 and VEGF in 51 esophagus squamous cell carcinoma tissues and 12 normal tissues, and to study the significance of expression of HMGB1 and VEGF protein.Results HMGB1 and VEGF expressions were closely correlated with lymph node metastasis(P<0.05),but not with tumor size,The expression of HMB1 was related with VEGF (r=0.476,P<0.05).Conclusions HMGB1 and VEGF are closely correlated with lymph node metastasis,the expression may become predictor to the prognosis of esophagus squamous cell carcinoma.